Title : Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells.

Pub. Date : 2007 May 1

PMID : 17483367






1 Functional Relationships(s)
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1 We now report that host MDSC have receptors for prostaglandin E2 (PGE2) and that E-prostanoid receptor agonists, including PGE2, induce the differentiation of Gr1(+)CD11b(+) MDSC from bone marrow stem cells, whereas receptor antagonists block differentiation. Dinoprostone integrin subunit alpha M Homo sapiens