Title : Gene expression of isoformic enzymes in arachidonate cyclooxygenase pathway and the regulation by tumor necrosis factor alpha during life cycle of adipocytes.

Pub. Date : 2007 May

PMID : 17481558






5 Functional Relationships(s)
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1 Using preadipogenic 3T3-L1 cells, we attempt to determine the response of adipocytes at different stages of the life cycle to TNFalpha with respect to the gene expression of the arachidonate cyclooxygenase (COX) pathway and the role of endogenous prostaglandins (PGs). Prostaglandins tumor necrosis factor Mus musculus
2 Using preadipogenic 3T3-L1 cells, we attempt to determine the response of adipocytes at different stages of the life cycle to TNFalpha with respect to the gene expression of the arachidonate cyclooxygenase (COX) pathway and the role of endogenous prostaglandins (PGs). Prostaglandins tumor necrosis factor Mus musculus
3 Moreover, the cells at different cycle stages exhibited the specific gene expression of isoformic enzymes of prostaglandin (PG) synthases for PGs of the D(2), E(2), and F(2alpha) series upon exposure to TNFalpha. Prostaglandins tumor necrosis factor Mus musculus
4 The cells during the differentiation phase were the most sensitive to TNFalpha in terms of the decrease in adipogenesis without the mediation of endogenous PGs. Prostaglandins tumor necrosis factor Mus musculus
5 The action of TNFalpha on preadipocytes can be modulated by the production of endogenous PGs through the induction of COX-2. Prostaglandins tumor necrosis factor Mus musculus