Title : Epidermal growth factor and transforming growth factor-beta1 enhance HK-2 cell migration through a synergistic increase of matrix metalloproteinase and sustained activation of ERK signaling pathway.

Pub. Date : 2007 Jul 1

PMID : 17467690






2 Functional Relationships(s)
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1 Inhibition of the ERK1/2 activity by PD98059 abrogated the synergistic effect of EGF and TGF-beta1 on cell migration, MMP-9 production and activity, indicating that EGF and TGF-beta1 converged at the ERK signaling pathway to mediate cell migration. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one epidermal growth factor Homo sapiens
2 Inhibition of the ERK1/2 activity by PD98059 abrogated the synergistic effect of EGF and TGF-beta1 on cell migration, MMP-9 production and activity, indicating that EGF and TGF-beta1 converged at the ERK signaling pathway to mediate cell migration. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one epidermal growth factor Homo sapiens