Title : Nicotine gates long-term potentiation in the hippocampal CA1 region via the activation of alpha2* nicotinic ACh receptors.

Pub. Date : 2007 May

PMID : 17466021






4 Functional Relationships(s)
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1 Interestingly, these opposing effects of nicotine were absent or greatly reduced in alpha2 nicotinic acetylcholine receptor (nAChR)-knockout (KO) mice, suggesting that an alpha2-containing nAChR subtype mediates these effects. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
2 These effects of nicotine were also absent in alpha2 nAChR-KO mice, suggesting that the enhanced optical signal is related to the nicotine-induced facilitation of LTP induction. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
3 These inhibitory effects of nicotine were absent in alpha2 nAChR-KO mice and, thus, most probably underlie the nicotine-induced suppression of LTP induction. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
4 These inhibitory effects of nicotine were absent in alpha2 nAChR-KO mice and, thus, most probably underlie the nicotine-induced suppression of LTP induction. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus