Pub. Date : 2007 Nov
PMID : 17457312
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | An increased activation of IDO and its subsequent enzyme kynurenine monooxygenase by proinflammatory cytokines, moreover, leads to an enhanced production of quinolinic acid, a strong agonist of the glutamatergic N-methyl-D-aspartate receptor. | Quinolinic Acid | indoleamine 2,3-dioxygenase 1 | Homo sapiens |
| 2 | In inflammatory states of the central nervous system, IDO is mainly activated in microglial cells, which preferentially metabolize tryptophan to the NMDA receptor agonist quinolinic acid, whereas astrocytes - counteracting this metabolism due to the lack of an enzyme of this metabolism - have been observed to be reduced in MD. | Quinolinic Acid | indoleamine 2,3-dioxygenase 1 | Homo sapiens |