Title : Genotype-phenotype based surgical concept of hereditary medullary thyroid carcinoma.

Pub. Date : 2007 May

PMID : 17453286






1 Functional Relationships(s)
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1 (2) Among the high-risk RET mutations, those in codon 634 cause higher penetrance rates of the multiple endocrine neoplasia 2A phenotype (MTC, pheochromocytoma, and parathyroid hyperplasia/adenoma) than mutations in codons 609, 611, 618, and 620, irrespective of the amino acid substituting for cysteine (grade C). Cysteine ret proto-oncogene Homo sapiens