Title : Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin.

Pub. Date : 2007 Jun 15

PMID : 17433672






1 Functional Relationships(s)
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1 The X-ray crystal structure of sitagliptin bound to DPP-4 suggested that the central beta-amino butyl amide moiety could be replaced with a cyclohexylamine group. Cyclohexylamines dipeptidyl peptidase 4 Homo sapiens