Pub. Date : 2007 Apr
PMID : 17431114
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | We hypothesized that inhibiting the phosphorylation of FAK and IGF-IR by NVP-TAE226 (hereafter called TAE226), a novel dual tyrosine kinase inhibitor of FAK and IGF-IR, would suppress the growth and invasion of glioma cells. | TAE226 | insulin like growth factor 1 receptor | Homo sapiens |
2 | We hypothesized that inhibiting the phosphorylation of FAK and IGF-IR by NVP-TAE226 (hereafter called TAE226), a novel dual tyrosine kinase inhibitor of FAK and IGF-IR, would suppress the growth and invasion of glioma cells. | TAE226 | insulin like growth factor 1 receptor | Homo sapiens |
3 | We hypothesized that inhibiting the phosphorylation of FAK and IGF-IR by NVP-TAE226 (hereafter called TAE226), a novel dual tyrosine kinase inhibitor of FAK and IGF-IR, would suppress the growth and invasion of glioma cells. | TAE226 | insulin like growth factor 1 receptor | Homo sapiens |
4 | We hypothesized that inhibiting the phosphorylation of FAK and IGF-IR by NVP-TAE226 (hereafter called TAE226), a novel dual tyrosine kinase inhibitor of FAK and IGF-IR, would suppress the growth and invasion of glioma cells. | TAE226 | insulin like growth factor 1 receptor | Homo sapiens |
5 | TAE226 also inhibited IGF-I-induced phosphorylation of IGF-IR and activity of its downstream target genes such as MAPK and Akt. | TAE226 | insulin like growth factor 1 receptor | Homo sapiens |
6 | Collectively, these data show that blocking the signaling pathways of FAK and IGF-IR with TAE226 has the potential to be an efficacious treatment for human gliomas. | TAE226 | insulin like growth factor 1 receptor | Homo sapiens |