Title : hOGG1 Ser326Cys polymorphism and susceptibility to gallbladder cancer in a Chinese population.

Pub. Date : 2007 Aug 1

PMID : 17417784






3 Functional Relationships(s)
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1 Significantly increased risk for gallbladder cancer was both the hOGG1 326Ser/Cys (Odds ratio [OR] = 1.9, 95% confidence interval (CI) = 1.0-3.7) and hOGG1 326Cys/Cys genotypes (OR = 4.5, 95% CI = 1.1-22.4). 326cys 8-oxoguanine DNA glycosylase Homo sapiens
2 In contrast, a near-significant increase in risk for gallbladder cancer was observed for gallstone presence with the hOGG1 326Ser/Cys genotype (OR = 2.2, CI = 1.4-3.5) whereas a significant increase in association for gallbladder cancer was observed for gallstone presence with the 326Cys/Cys genotype (OR = 6.1, CI = 2.1-27.2). 326cys 8-oxoguanine DNA glycosylase Homo sapiens
3 A significant increase in risk for gallbladder cancer was observed for larger gallstone (those with stone diameters 2 cm or greater) with the hOGG1 326Ser/Cys(OR = 1.9, 95% CI = 1.1-2.9) and hOGG1 326Cys/Cys genotypes(OR = 5.9, 95% CI = 1.6-18.0). 326cys 8-oxoguanine DNA glycosylase Homo sapiens