Pub. Date : 2007 Apr
PMID : 17409494
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A novel cyclophane compound, CPPy, facilitates NGF-induced TrkA signal transduction and induces cell differentiation in neuroblastoma. | cppy | neurotrophic receptor tyrosine kinase 1 | Homo sapiens |
| 2 | A novel cyclophane, cyclophane pyridine (CPPy), was designed to conserve the tyrosine phosphorylation of TrkA, thereby enhancing NGF/TrkA signal transduction. | cppy | neurotrophic receptor tyrosine kinase 1 | Homo sapiens |
| 3 | A novel cyclophane, cyclophane pyridine (CPPy), was designed to conserve the tyrosine phosphorylation of TrkA, thereby enhancing NGF/TrkA signal transduction. | cppy | neurotrophic receptor tyrosine kinase 1 | Homo sapiens |
| 4 | As determined by Western blotting, TrkA (Y490) phosphorylation was enhanced by the combination of CPPy (10(-8) M) and NGF (100 ng/ml) compared with NGF alone. | cppy | neurotrophic receptor tyrosine kinase 1 | Homo sapiens |
| 5 | These data suggest that CPPy can induce the differentiation of NB cell lines by facilitating NGF-induced TrkA/Ras/MAPK signal transduction, and may therefore be an effective therapeutic agent for NB. | cppy | neurotrophic receptor tyrosine kinase 1 | Homo sapiens |