Title : Overexpression of integrin beta1 inhibits proliferation of hepatocellular carcinoma cell SMMC-7721 through preventing Skp2-dependent degradation of p27 via PI3K pathway.

Pub. Date : 2007 Oct 15

PMID : 17407140






2 Functional Relationships(s)
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1 PI3K inhibitor LY294002 upregulated p27(Kip1) at post-translational level and downregulate Skp2 at mRNA level, which could mimic the effects of integrin beta1 overexpression on p27(Kip1) and Skp2. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one cyclin dependent kinase inhibitor 1B Homo sapiens
2 PI3K inhibitor LY294002 upregulated p27(Kip1) at post-translational level and downregulate Skp2 at mRNA level, which could mimic the effects of integrin beta1 overexpression on p27(Kip1) and Skp2. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one cyclin dependent kinase inhibitor 1B Homo sapiens