Pub. Date : 2007 Apr 15
PMID : 17404287
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We previously demonstrated that genistein suppresses TNF-alpha-induced NF-kappaB-dependent IL-6 gene expression in cancer cells by interfering with the mitogen- and stress-activated protein kinase 1 activation pathway. | Genistein | interleukin 6 | Homo sapiens |
| 2 | More particularly, we observe that genistein inhibits IL-6 gene expression by modulating the transcription factor NF-kappaB. | Genistein | interleukin 6 | Homo sapiens |
| 3 | Moreover, analysis of IL-6 mRNA levels in bone marrow-derived p53 null vs wild-type dendritic cells confirms a role for p53 in the reduction of NF-kappaB-dependent gene expression, mediated by genistein. | Genistein | interleukin 6 | Homo sapiens |