Pub. Date : 2007 Apr 24
PMID : 17398000
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Raloxifene blocks estradiol induction of the serotonin transporter and 5-hydroxytryptamine2A receptor in female rat brain. | Estradiol | solute carrier family 6 member 4 | Rattus norvegicus |
| 2 | Specifically, estradiol-17beta in its acute positive feedback mode for gonadotropin release in the female rat induces expression of the genes for the 5-hydroxytryptamine(2A) receptor (5-HT(2A)R) and the serotonin transporter (SERT) in the dorsal raphe nucleus (DRN). | Estradiol | solute carrier family 6 member 4 | Rattus norvegicus |
| 3 | Specifically, estradiol-17beta in its acute positive feedback mode for gonadotropin release in the female rat induces expression of the genes for the 5-hydroxytryptamine(2A) receptor (5-HT(2A)R) and the serotonin transporter (SERT) in the dorsal raphe nucleus (DRN). | Estradiol | solute carrier family 6 member 4 | Rattus norvegicus |
| 4 | Here we report that raloxifene, a benzothiophene and selective estrogen receptor modulator (SERM), completely blocked estradiol stimulation of brain 5-HT(2A)R and SERT expression in acutely ovariectomized rats. | Estradiol | solute carrier family 6 member 4 | Rattus norvegicus |
| 5 | These findings provide robust evidence that estradiol induction of the 5-HT(2A)R and the SERT in brain is mediated by nuclear estrogen receptors. | Estradiol | solute carrier family 6 member 4 | Rattus norvegicus |