Pub. Date : 2007 Jul
PMID : 17395695
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Receptor-mediated suppression of cardiac heat-shock protein 72 expression by testosterone in male rat heart. | Testosterone | heat shock protein family A (Hsp70) member 1A | Rattus norvegicus |
| 2 | The impact of testosterone on cardiac expression of heat-shock protein 72 (HSP72) remains to be elucidated. | Testosterone | heat shock protein family A (Hsp70) member 1A | Rattus norvegicus |
| 3 | The impact of testosterone on cardiac expression of heat-shock protein 72 (HSP72) remains to be elucidated. | Testosterone | heat shock protein family A (Hsp70) member 1A | Rattus norvegicus |
| 4 | We observed the following: 1) Exogenous testosterone suppressed HT-induced HSP72 expression, but castration alone had no influence. | Testosterone | heat shock protein family A (Hsp70) member 1A | Rattus norvegicus |
| 5 | 3) HT-induced HSP72 expression in cultured cardiomyocytes was suppressed by testosterone. | Testosterone | heat shock protein family A (Hsp70) member 1A | Rattus norvegicus |
| 6 | 5) Flutamide, a testosterone receptor blocker, cancelled the suppressive effects of testosterone on HSP72 expression. | Testosterone | heat shock protein family A (Hsp70) member 1A | Rattus norvegicus |
| 7 | Our results indicate that testosterone potentially has inhibitory effects on cardiac HSP72 expression by modulating transcription, through testosterone receptor-mediated genomic mechanisms. | Testosterone | heat shock protein family A (Hsp70) member 1A | Rattus norvegicus |