Protein Name heat shock protein family A (Hsp70) member 1A
Organism Rattus norvegicus
Gene ID 24472
Gene Symbol

Hspa1a

UniProt P0DMW0 (HS71A_RAT), P0DMW1 (HS71B_RAT)
Relationships Total Number of functionally related compound(s) : 198
Total Number of Articles : 224
Description

heat shock protein family A (Hsp70) member 1A

Gene Summary

Enables NF-kappaB binding activity and protease binding activity. Involved in several processes, including negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of vasoconstriction; and positive regulation of T cell mediated cytotoxicity. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and membrane raft. Part of protein-containing complex. Human ortholog(s) of this gene implicated in several diseases, including brain ischemia; obesity; toxic shock syndrome; type 2 diabetes mellitus; and urinary tract infection. Orthologous to human HSPA1B (heat shock protein family A (Hsp70) member 1B). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • heat shock 70 kDa protein 1A
  • HSP70-1/HSP70-2
  • HSP70.1/2
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Properties