Pub. Date : 2007 May 25
PMID : 17395382
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sustained exposure to opioid agonists such as morphine increases levels of calcitonin gene-related peptide (CGRP) in the spinal dorsal horn, a response implicated in the development of opioid tolerance and physical dependence. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 2 | Sustained exposure to opioid agonists such as morphine increases levels of calcitonin gene-related peptide (CGRP) in the spinal dorsal horn, a response implicated in the development of opioid tolerance and physical dependence. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 3 | In another set of experiments, chronic administration of spinal morphine (15 microg) once daily for 5 days produced a similar loss of analgesic effect and a marked increase in CGRP-immunoreactivity in the superficial laminae of the dorsal horn. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 4 | Consistent with the in vivo findings, primary cultures of adult dorsal root ganglion (DRG) neurons exposed to morphine for 5 days showed a significant increase in the number of CGRP-immunoreactive neurons. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 5 | Co-administration with AM-251 attenuated the morphine-induced increase in CGRP-immunoreactivity in the spinal cord and in DRG cultured neurons. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |