Title : Role of TLR4 tyrosine phosphorylation in signal transduction and endotoxin tolerance.

Pub. Date : 2007 Jun 1

PMID : 17392283






1 Functional Relationships(s)
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1 Mutations of tyrosine residues Y674A and Y680A within the TIR domains of CD4-TLR4 impaired its ability to elicit phosphorylation of p38 and JNK mitogen-activated protein kinases, IkappaB-alpha degradation, and activation of NF-kappaB and RANTES reporters. Tyrosine CD4 molecule Homo sapiens