Title : Filamin A-mediated down-regulation of the exchange factor Ras-GRF1 correlates with decreased matrix metalloproteinase-9 expression in human melanoma cells.

Pub. Date : 2007 May 18

PMID : 17389601






1 Functional Relationships(s)
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1 Experimental evidence indicated that this phenomenon was associated with destabilization and ubiquitylation of Ras-GRF1, a guanine nucleotide exchange factor that activates H-Ras by facilitating the release of GDP. Guanosine Diphosphate Ras protein specific guanine nucleotide releasing factor 1 Homo sapiens