Title : Phosphorylation of the survival kinase Akt by superoxide is dependent on an ascorbate-reversible oxidation of PTEN.

Pub. Date : 2007 Apr 15

PMID : 17382199






1 Functional Relationships(s)
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1 In this report, we demonstrate that in serum-deprived mouse embryonic fibroblasts an increase in intracellular level of superoxide through pharmacological inhibition of the Cu/ZnSOD protein or the down-regulation of its expression using specific siRNA mimics growth factor-induced phosphorylation of Akt. Superoxides superoxide dismutase 1, soluble Mus musculus