Title : Acid sphingomyelinase is required for lipid Raft TLR4 complex formation.

Pub. Date : 2007 Feb

PMID : 17381401






1 Functional Relationships(s)
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1 PURPOSE: We determined whether LPS-induced TLR4 assembly and activation are dependent on the sphingolipid metabolite ceramide, produced by acid sphingomyelinase following the initial binding of LPS to CD14. Sphingolipids CD14 molecule Homo sapiens