Pub. Date : 2007 Apr
PMID : 17376120
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We therefore correlated intestinal expression levels and genetics of CYP3A4, CYP2C9/19, MDR1 and MRP2 with dose requirement and plasma levels of carbamazepine and phenytoin. | Carbamazepine | ATP binding cassette subfamily C member 2 | Homo sapiens |
| 2 | Furthermore, carbamazepine dose was positively correlated with MRP2 expression (P = 0.1). | Carbamazepine | ATP binding cassette subfamily C member 2 | Homo sapiens |
| 3 | CONCLUSION: Differences in intestinal MDR1 and MRP2 expression may influence carbamazepine and phenytoin disposition and may account for interindividual pharmacokinetic variability. | Carbamazepine | ATP binding cassette subfamily C member 2 | Homo sapiens |