Title : Functional expression of human dihydroorotate dehydrogenase (DHODH) in pyr4 mutants of ustilago maydis allows target validation of DHODH inhibitors in vivo.

Pub. Date : 2007 May

PMID : 17369345






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 DHODH is an important target for antiparasitic and cytostatic drugs since rapid cell proliferation often depends on the de novo synthesis of pyrimidine nucleotides. Pyrimidine Nucleotides dihydroorotate dehydrogenase (quinone) Homo sapiens