Title : Compartmentalization of signaling-competent epidermal growth factor receptors in endosomes.

Pub. Date : 2007 Jun

PMID : 17363458






3 Functional Relationships(s)
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1 Both of these techniques show that after EGF administration, a distinctive population of intracellular EGFR, which was characterized by a high level of tyrosine phosphorylation, accumulated in endosomes. Tyrosine epidermal growth factor receptor Rattus norvegicus
2 EGFR recruited to early endosomes were more tyrosine phosphorylated than those from late endosomes. Tyrosine epidermal growth factor receptor Rattus norvegicus
3 However, the level of tyrosine phosphorylation of EGFR in DRMs isolated from early and late endosomes was comparable, suggesting that EGFR in endosomal DRMs are more resistant to tyrosine dephosphorylation. Tyrosine epidermal growth factor receptor Rattus norvegicus