Title : Targeting homeostatic mechanisms of endoplasmic reticulum stress to increase susceptibility of cancer cells to fenretinide-induced apoptosis: the role of stress proteins ERdj5 and ERp57.

Pub. Date : 2007 Apr 10

PMID : 17353921






1 Functional Relationships(s)
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1 In contrast to the apoptosis-inducing chemotherapeutic drugs vincristine and temozolomide, fenretinide induced the phosphorylation of eIF2alpha, expression of ATF4 and splicing of XBP-1 mRNA, events that define ER stress. Fenretinide eukaryotic translation initiation factor 2A Homo sapiens