Title : Flexible estrogen receptor modulators: synthesis, biochemistry and molecular modeling studies for 3-benzyl-4,6-diarylhex-3-ene and 3,4,6-triarylhex-3-ene derivatives.

Pub. Date : 2007 Mar

PMID : 17348852






1 Functional Relationships(s)
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1 The structure-activity relationships for the active ligands were further explored in a computational study where docked structures of the active compounds were compared with the X-ray crystal structures for the complexes of ER alpha with 4-hydroxytamoxifen and ER beta with raloxifene. Raloxifene Hydrochloride estrogen receptor 2 Homo sapiens