Title : Cyclosporin A and FK506 inhibit IL-12p40 production through the calmodulin/calmodulin-dependent protein kinase-activated phosphoinositide 3-kinase in lipopolysaccharide-stimulated human monocytic cells.

Pub. Date : 2007 May 4

PMID : 17347151






1 Functional Relationships(s)
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1 Importantly, both CyA and FK506 down-regulated LPS-induced IL-12p40 transcription by inhibiting CaM/CaMK-II-activated PI3K and their downstream transcription factors NFkappaB and AP-1 independent of the JNK pathway. Tacrolimus nuclear factor kappa B subunit 1 Homo sapiens