Title : Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted receptor tyrosine kinase inhibitor.

Pub. Date : 2007 Apr 5

PMID : 17343372






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N"-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted receptor tyrosine kinase inhibitor. 1H-Indazol-3-amine ret proto-oncogene Homo sapiens
2 In our continued efforts to search for potent and novel receptor tyrosine kinase (RTK) inhibitors as potential anticancer agents, we discovered, through a structure-based design, that 3-aminoindazole could serve as an efficient hinge-binding template for kinase inhibitors. 1H-Indazol-3-amine ret proto-oncogene Homo sapiens
3 In our continued efforts to search for potent and novel receptor tyrosine kinase (RTK) inhibitors as potential anticancer agents, we discovered, through a structure-based design, that 3-aminoindazole could serve as an efficient hinge-binding template for kinase inhibitors. 1H-Indazol-3-amine ret proto-oncogene Homo sapiens