Pub. Date : 2007 Mar 1
PMID : 17332344
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | APE1/Ref-1 decrease correlated with decreased DNA-binding activity of NF-kappaB mediated by soy isoflavones and radiation, thus promoting cell killing. | Isoflavones | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | In vivo treatment of prostate tumors with soy isoflavones and radiation down-regulated APE1/Ref-1 protein expression and NF-kappaB activity, confirming the molecular alterations observed in vitro. | Isoflavones | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | The down-regulation of APE1/Ref-1 and NF-kappaB by isoflavones, in vitro and in vivo, supports our hypothesis that these markers represent biological targets of isoflavones. | Isoflavones | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | The down-regulation of APE1/Ref-1 and NF-kappaB by isoflavones, in vitro and in vivo, supports our hypothesis that these markers represent biological targets of isoflavones. | Isoflavones | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | Indeed, a 2-fold increase in APE1/Ref-1 expression, obtained by cDNA transfection, resulted in a 2-fold increase in NF-kappaB DNA-binding activity, and both of which were down-regulated by soy isoflavones, confirming the cross-talk between these molecules and, in turn, causing radiosensitization. | Isoflavones | nuclear factor kappa B subunit 1 | Homo sapiens |