Pub. Date : 2007 Apr 15
PMID : 17330857
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Histone deacetylase inhibitor trichostatin a potentiates doxorubicin-induced apoptosis by up-regulating PTEN expression. | Doxorubicin | phosphatase and tensin homolog | Homo sapiens |
| 2 | Overexpression of PTEN by adenoviral transfection increases doxorubicin-induced apoptosis. | Doxorubicin | phosphatase and tensin homolog | Homo sapiens |
| 3 | The aim of this work was to investigate whether changes in PTEN expression are involved in TSA/doxorubicin-induced apoptosis. | Doxorubicin | phosphatase and tensin homolog | Homo sapiens |
| 4 | RESULTS: Doxorubicin-induced apoptosis was enhanced by TSA, whereas small interfering RNA (siRNA) targeting PTEN inhibited TSA/doxorubicin-induced apoptosis. | Doxorubicin | phosphatase and tensin homolog | Homo sapiens |
| 5 | CONCLUSIONS: TSA promoted doxorubicin-induced apoptosis through a mechanism that involved the stimulation of Egr-1 expression, acetylation of core histones at the PTEN promoter, and consequently induction of PTEN transcription. | Doxorubicin | phosphatase and tensin homolog | Homo sapiens |
| 6 | CONCLUSIONS: TSA promoted doxorubicin-induced apoptosis through a mechanism that involved the stimulation of Egr-1 expression, acetylation of core histones at the PTEN promoter, and consequently induction of PTEN transcription. | Doxorubicin | phosphatase and tensin homolog | Homo sapiens |