Pub. Date : 2007 Nov
PMID : 17327885
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Chronic duloxetine treatment induces specific changes in the expression of BDNF transcripts and in the subcellular localization of the neurotrophin protein. | Duloxetine Hydrochloride | brain-derived neurotrophic factor | Rattus norvegicus |
| 2 | In the present study, we investigated the effects of the novel antidepressant duloxetine on BDNF in the rat brain. | Duloxetine Hydrochloride | brain-derived neurotrophic factor | Rattus norvegicus |
| 3 | We found that chronic, but not acute, treatment with duloxetine produces a robust increase of exon V BDNF mRNA levels in frontal cortex when the animals were killed 1 or 24 h after the last administration. | Duloxetine Hydrochloride | brain-derived neurotrophic factor | Rattus norvegicus |
| 4 | Protein analysis in different subcellular fractions showed that chronic treatment with duloxetine, but not with the prototypical SSRI fluoxetine, reduced mature BDNF in the cytosol, but markedly increased its levels in the crude synaptosomal fraction. | Duloxetine Hydrochloride | brain-derived neurotrophic factor | Rattus norvegicus |
| 5 | Our data suggest that chronic treatment with the novel antidepressant duloxetine not only produces a marked upregulation of BDNF mRNA and protein, but may also affect the subcellular redistribution of the neurotrophin. | Duloxetine Hydrochloride | brain-derived neurotrophic factor | Rattus norvegicus |