Title : Reduced folate carrier-1 80G>A polymorphism affects methotrexate treatment outcome in rheumatoid arthritis.

Pub. Date : 2007 Dec

PMID : 17325736






3 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 MTX enters the cells through the reduced folate carrier (RFC-1) and is activated to polyglutamates. Folic Acid replication factor C subunit 1 Homo sapiens
2 The studies suggest that G80A polymorphism in RFC-1 is associated with altered folate/antifolate levels and the subjects carrying homozygous mutant 80AA genotype tend to have higher plasma folate and MTX concentrations and higher erythrocyte polyglutamate levels compared with those with the wild type or heterozygous genotype. Folic Acid replication factor C subunit 1 Homo sapiens
3 The studies suggest that G80A polymorphism in RFC-1 is associated with altered folate/antifolate levels and the subjects carrying homozygous mutant 80AA genotype tend to have higher plasma folate and MTX concentrations and higher erythrocyte polyglutamate levels compared with those with the wild type or heterozygous genotype. Folic Acid replication factor C subunit 1 Homo sapiens