Title : Protein kinase C-ERK1/2 signal pathway switches glucose depletion-induced necrosis to apoptosis by regulating superoxide dismutases and suppressing reactive oxygen species production in A549 lung cancer cells.

Pub. Date : 2007 May

PMID : 17309078






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Inhibition of ROS production by N-acetyl-L-cysteine and catalase prevented necrosis and switched the cell death mode to apoptosis that depends on mitochondrial death pathway involving caspase-9 and caspase-3 activation, indicating a critical role of ROS in determination of GD-induced cell death mode. Reactive Oxygen Species caspase 9 Homo sapiens