Title : Targeted therapy of orthotopic human lung cancer by combined vascular endothelial growth factor and epidermal growth factor receptor signaling blockade.

Pub. Date : 2007 Feb

PMID : 17308046






1 Functional Relationships(s)
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1 In vitro, ZD6474 inhibited EGFR, VEGFR2, mitogen-activated protein kinase and Akt phosphorylation, EGF- and VEGF-induced proliferation, and endothelial cell tube formation and also induced apoptosis. vandetanib AKT serine/threonine kinase 1 Homo sapiens