Title : Effect of physiologic shear stresses and calcium on agonist-induced platelet aggregation, secretion, and thromboxane A2 formation.

Pub. Date : 2007

PMID : 17306868






2 Functional Relationships(s)
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1 RESULTS AND CONCLUSIONS: ADP and thrombin induced similar strong levels of aggregation ( approximately 70%) at high shear by 5 s. Thrombin also caused release of about 40% of all alpha and dense granules within 5 s. However, by 5 s at high shear, ADP failed to induce significant granule secretion or thromboxane A(2) formation (<5%, p>0.05). thromboxane a coagulation factor II, thrombin Homo sapiens
2 RESULTS AND CONCLUSIONS: ADP and thrombin induced similar strong levels of aggregation ( approximately 70%) at high shear by 5 s. Thrombin also caused release of about 40% of all alpha and dense granules within 5 s. However, by 5 s at high shear, ADP failed to induce significant granule secretion or thromboxane A(2) formation (<5%, p>0.05). thromboxane a coagulation factor II, thrombin Homo sapiens