Title : Crystal structures of phosphodiesterases and implications on substrate specificity and inhibitor selectivity.

Pub. Date : 2007

PMID : 17305581






2 Functional Relationships(s)
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1 The PDE4-AMP and PDE5-GMP structures reveal the conserved interactions of the phosphate groups of the products AMP and GMP, and thus suggest a universal mechanism of nucleophilic attack for all PDE families. guanosine 5'-monophosphorothioate phosphodiesterase 5A Homo sapiens
2 The PDE4-AMP and PDE5-GMP structures reveal the conserved interactions of the phosphate groups of the products AMP and GMP, and thus suggest a universal mechanism of nucleophilic attack for all PDE families. guanosine 5'-monophosphorothioate phosphodiesterase 5A Homo sapiens