Pub. Date : 2007 Mar 13
PMID : 17288452
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the absence of sodium, various sugars significantly decreased the intrinsic Trp fluorescence of hSGLT1 in proteoliposomes exhibiting the following sequence of affinities: alpha-MDG > d-glucose approximately d-galactose > 6-deoxy-d-glucose > 2-deoxy-d-glucose > d-allose. | Tryptophan | solute carrier family 5 member 1 | Homo sapiens |
| 2 | This Trp residue is conserved in all known SGLT1 forms (except Vibrio parahaemolyticus SGLT) and all SGLT isoforms in humans (except hSGLT3). | Tryptophan | solute carrier family 5 member 1 | Homo sapiens |
| 3 | If all these data are taken into consideration, it seems that Trp-561 in hSGLT1 forms part of a low-affinity sodium-independent binding and/or translocation site for d-glucose. | Tryptophan | solute carrier family 5 member 1 | Homo sapiens |