Title : Schedule-dependent cytotoxicity of 5-fluorouracil and irinotecan in a colon cancer cell line.

Pub. Date : 2006 Dec

PMID : 17287894






1 Functional Relationships(s)
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1 Reverse transcription-polymerase chain reaction analysis revealed that exposure to 5-FU downregulated both MDR1 and bcl-2 mRNA and simultaneously upregulated CE2 mRNA expression, suggesting enhancement of subsequent CPT-11 cytotoxicity. Fluorouracil BCL2 apoptosis regulator Homo sapiens