Pub. Date : 2007 Mar 20
PMID : 17286987
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotine-induced vascular endothelial growth factor release via the EGFR-ERK pathway in rat vascular smooth muscle cells. | Nicotine | vascular endothelial growth factor A | Rattus norvegicus |
| 2 | In the present study, we investigated the effects of nicotine, which is one of the important constituents of cigarette smoke, on vascular endothelial growth factor (VEGF) release, in rat VSMC. | Nicotine | vascular endothelial growth factor A | Rattus norvegicus |
| 3 | In the present study, we investigated the effects of nicotine, which is one of the important constituents of cigarette smoke, on vascular endothelial growth factor (VEGF) release, in rat VSMC. | Nicotine | vascular endothelial growth factor A | Rattus norvegicus |
| 4 | The stimulation of cells with nicotine resulted in a time- and concentration-dependent release of VEGF. | Nicotine | vascular endothelial growth factor A | Rattus norvegicus |
| 5 | Hexamethonium, an antagonist of nicotinic acetylcholine receptor (nAChR), inhibited nicotine-induced VEGF release. | Nicotine | vascular endothelial growth factor A | Rattus norvegicus |
| 6 | We next investigated the mechanisms by which nicotine induces VEGF release in the cells. | Nicotine | vascular endothelial growth factor A | Rattus norvegicus |
| 7 | The nicotine-induced VEGF release was inhibited by treatment with U0126, a selective inhibitor of MEK, which attenuated the nicotine-induced ERK phosphorylation. | Nicotine | vascular endothelial growth factor A | Rattus norvegicus |
| 8 | The nicotine-induced VEGF release was inhibited by treatment with U0126, a selective inhibitor of MEK, which attenuated the nicotine-induced ERK phosphorylation. | Nicotine | vascular endothelial growth factor A | Rattus norvegicus |
| 9 | Furthermore, AG1478, a selective inhibitor of epidermal growth factor receptor (EGFR) kinase, inhibited nicotine-induced ERK phosphorylation and VEGF release. | Nicotine | vascular endothelial growth factor A | Rattus norvegicus |
| 10 | These data suggest that nicotine releases VEGF through nAChR in VSMC. | Nicotine | vascular endothelial growth factor A | Rattus norvegicus |
| 11 | Moreover, VEGF release induced by nicotine is mediated by an EGFR-ERK pathway in VSMC. | Nicotine | vascular endothelial growth factor A | Rattus norvegicus |