Title : Signaling mechanisms of melatonin in antiproliferation of hormone-refractory 22Rv1 human prostate cancer cells: implications for prostate cancer chemoprevention.

Pub. Date : 2007 Mar

PMID : 17286752






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Melatonin inhibited, concentration dependently, cell proliferation, upregulated p27(Kip1) gene transcription and protein expression, and downregulated activated androgen signaling in 22Rv1 cells. Melatonin cyclin dependent kinase inhibitor 1B Homo sapiens
2 Importantly, we discovered that the antiproliferative effect of melatonin exerted via MT(1) receptor on p27(Kip1) gene and protein upregulation is mediated by a novel signaling mechanism involving co-activation of protein kinase C (PKC) and PKA in parallel. Melatonin cyclin dependent kinase inhibitor 1B Homo sapiens