Title : Activation of phospholipase D by glyceraldehyde in isolated islet cells follows protein kinase C activation.

Pub. Date : 1992 Jan

PMID : 1727727






3 Functional Relationships(s)
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1 Activation of phospholipase D by glyceraldehyde in isolated islet cells follows protein kinase C activation. Glyceraldehyde glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens
2 Experimental confirmation of a concentration-dependent specific activation of PLD was provided by the formation of a transphosphatidylation product, phosphatidylethanol, after stimulation with glyceraldehyde in the presence of added ethanol (1.5%). Glyceraldehyde glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens
3 The finding of an early rise in glyceraldehyde-stimulated diacylglycerol (which may be formed de novo or by the action of phospholipase C), suggests that PLD is recruited by the activation of protein kinase C by this nutrient. Glyceraldehyde glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens