Title : Fenretinide up-regulates DR5/TRAIL-R2 expression via the induction of the transcription factor CHOP and combined treatment with fenretinide and TRAIL induces synergistic apoptosis in colon cancer cell lines.

Pub. Date : 2007 Mar

PMID : 17273769






1 Functional Relationships(s)
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1 Fenretinide and TRAIL cooperatively activated caspase-3, -8, -10 and -9 and cleavage of Bid and PARP, and this activation was also blocked in the presence of DR5/Fc chimeric protein. Fenretinide BH3 interacting domain death agonist Homo sapiens