Pub. Date : 2007 Jun
PMID : 17272824
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Parthenolide significantly inhibited IL-8 secretion induced by these cytokines and prevented NF-kappaB activation, IkappaBalpha degradation, and IkappaB Kinase complex activity. | parthenolide | nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha | Mus musculus |
| 2 | We thus conclude that parthenolide inhibits IkappaB kinase, resulting in stabilization of cytoplasmic IkappaBalpha, which in turn leads to inhibition of NF-kappaB translocation and attenuation of subsequent inflammatory responses. | parthenolide | nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha | Mus musculus |