Title : p200 RhoGAP promotes cell proliferation by mediating cross-talk between Ras and Rho signaling pathways.

Pub. Date : 2007 Mar 23

PMID : 17272280






2 Functional Relationships(s)
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1 Interestingly, the RhoGAP activity of the N-terminal RhoGAP domain in p200 RhoGAP is also required for its full transforming activity, and expression of a dominant negative RhoA mutant that blocks RhoA cycling between the GDP- and GTP-bound states suppresses p200 RhoGAP transformation. Guanosine Diphosphate ras homolog family member A Homo sapiens
2 Interestingly, the RhoGAP activity of the N-terminal RhoGAP domain in p200 RhoGAP is also required for its full transforming activity, and expression of a dominant negative RhoA mutant that blocks RhoA cycling between the GDP- and GTP-bound states suppresses p200 RhoGAP transformation. Guanosine Diphosphate ras homolog family member A Homo sapiens