Title : Ribophorin I acts as a substrate-specific facilitator of N-glycosylation.

Pub. Date : 2007 Feb 15

PMID : 17264154






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The mammalian oligosaccharyltransferase (OST) complex is composed of about eight subunits and mediates the N-glycosylation of nascent polypeptide chains entering the endoplasmic reticulum (ER). Nitrogen dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit Homo sapiens
2 The mammalian oligosaccharyltransferase (OST) complex is composed of about eight subunits and mediates the N-glycosylation of nascent polypeptide chains entering the endoplasmic reticulum (ER). Nitrogen dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit Homo sapiens
3 We propose a new model for OST function where ribophorin I acts as a chaperone or escort to promote the N-glycosylation of selected substrates by the catalytic STT3 subunits. Nitrogen dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit Homo sapiens