Pub. Date : 2007 Apr
PMID : 17259447
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | N-Demethylation of methadone in vitro is predominantly mediated by cytochrome P450 CYP3A4 and CYP2B6 and somewhat by CYP2C19. | Methadone | cytochrome P450 family 2 subfamily C member 19 | Homo sapiens |
| 2 | This investigation evaluated stereoselectivity, models, and kinetic parameters for methadone N-demethylation by recombinant CYP2B6, CYP3A4, and CYP2C19, and the potential for interactions between enantiomers during racemate metabolism. | Methadone | cytochrome P450 family 2 subfamily C member 19 | Homo sapiens |