Title : Blockade of cytokine-induced endothelial cell adhesion molecule expression by licorice isoliquiritigenin through NF-kappaB signal disruption.

Pub. Date : 2007 Feb

PMID : 17259331






2 Functional Relationships(s)
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1 Isoliquiritigenin downregulated CAM proteins in TNF-alpha-activated HUVEC at the transcriptional levels by blocking degradation of IkappaBalpha and nuclear translocation of NF-kappaB. isoliquiritigenin nuclear factor kappa B subunit 1 Homo sapiens
2 These results demonstrate that the induction blockade of VCAM-1 and E-selectin by isoliquiritigenin was directly mediated by its interference with the CAM mRNA transcription through NF-kappaB-dependent mechanisms under inflammatory conditions. isoliquiritigenin nuclear factor kappa B subunit 1 Homo sapiens