Title : PKCepsilon is essential for gelsolin expression by histone deacetylase inhibitor apicidin in human cervix cancer cells.

Pub. Date : 2007 Mar 16

PMID : 17257588






3 Functional Relationships(s)
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1 PKCepsilon is essential for gelsolin expression by histone deacetylase inhibitor apicidin in human cervix cancer cells. apicidin protein kinase C epsilon Homo sapiens
2 In this study, we show that protein kinase C (PKC) signaling pathway is required for the induction of gelsolin by the histone deacetylase inhibitor apicidin in HeLa cells. apicidin protein kinase C epsilon Homo sapiens
3 Furthermore, inhibition of PKCepsilon by either siRNA or dominant-negative mutant completely abrogates the expression of gelsolin by apicidin, indicating that PKCepsilon is the major isoform for this process. apicidin protein kinase C epsilon Homo sapiens