Title : Defective insulin and acetylcholine induction of endothelial cell-nitric oxide synthase through insulin receptor substrate/Akt signaling pathway in aorta of obese rats.

Pub. Date : 2007 Apr

PMID : 17229938






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Upon JAK2 activation, tyrosine phosphorylation of insulin receptor substrate (IRS)-1 is detected. Tyrosine Janus kinase 2 Rattus norvegicus
2 These data indicate a new signal transduction pathway for IRS-1/PI 3-kinase/Akt/eNOS activation and ERK1/2 by means of JAK2 tyrosine phosphorylation stimulated by ACh in vessels. Tyrosine Janus kinase 2 Rattus norvegicus