Title : Tyrosine kinase Syk associates with toll-like receptor 4 and regulates signaling in human monocytic cells.

Pub. Date : 2007 Apr-May

PMID : 17228323






2 Functional Relationships(s)
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1 Piceatannol, a pharmacological inhibitor of the tyrosine kinase Syk, abrogates TLR4 tyrosine phosphorylation at low doses. 3,3',4,5'-tetrahydroxystilbene spleen associated tyrosine kinase Homo sapiens
2 Finally, the inhibition of Syk with piceatannol has no effect on LPS-mediated release of cytokines IL6, IL1beta, tumor necrosis factor-alpha, neither on chemokines macrophage inhibitory protein (MIP)1alpha, MIP1beta, monocyte chemoattractant protein -1, IL8, Groalpha and RANTES. 3,3',4,5'-tetrahydroxystilbene spleen associated tyrosine kinase Homo sapiens