Title : Heparin suppresses lipid raft-mediated signaling and ligand-independent EGF receptor activation.

Pub. Date : 2007 Apr

PMID : 17226785






2 Functional Relationships(s)
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1 In these situations, heparin inhibits phosphorylation of EGFR on the Src-dependent site Tyr(845), but not the autophosphorylation of Tyr(1173), and decreases Ras activation and Erk phosphorylation. Heparin mitogen-activated protein kinase 1 Homo sapiens
2 We conclude that heparin can suppress Erk signaling in VSMC with effects on site-specific phosphorylation of EGFR localized in caveolin-enriched lipid rafts. Heparin mitogen-activated protein kinase 1 Homo sapiens